After marijuana smoking, there was also a significant increase in cerebral blood flow, respiration, pulse rate, and systolic blood pressure. Eighty-six percent of the subjects reported at least some temporal disintegration after high-potency marijuana. As will be described in Chapter 8, it has been established that cannabis and other drugs can reliably induce depersonalization in a dose-dependent manner. For many of us it comes in waves and seems to be incredibly hard to pin down. After the marijuana is long gone there seems to be a lingering anxiety and derealization that can last a few days or a few weeks. The changes were most marked 30 minutes after smoking the high-potency cigarettes. There seems to be a thing that happens to some of us who smoke too much and have a panic attack during our first few times with marijuana. Marijuana smoking, but not placebo smoking, was associated with significant temporal disintegration and depersonalization. However, this type of dissociative disorder is not typically addressed in contemporary reviews focusing on the implications of cannabis use ( 2 ). The psychological indices were cerebral blood flow, pulse, respiration, and end tidal carbon dioxide and carbon monoxide. Cannabis-induced depersonalization-derealization disorder has been described in the literature for many years ( 10, 11 ). The psychological indices monitored consisted of temporal disintegration, depersonalization, and mood states. Psychological and physiological indices were monitored before and 120 minutes after smoking high- and low-potency marijuana cigarettes and a placebo cigarette in 35 physically and psychiatrically healthy normal volunteers during three separate visits to the laboratory. The observation that depersonalization emerges after smoking marijuana naturally transforms into a belief that depersonalization appears because of smoking marijuana.

Weed depersonalization